- Alpha-1 Antitrypsin Deficiency
- Prevalence
- Signs/Manifestations
- Alpha-1 differential:
- Emphysema
- COPD
- Asthma
- Bronchitis
- Etiology & Heredity
For questions or assistance, call customer service: 1-800-305-7881
Patients enrolled in Prolastin Direct experienced 10% fewer exacerbations.1
Prolastin Direct Alpha-1 health management program helps improve patient outcomes.
Learn more about Alpha-1 Disease Management and Prevention Program (ADMAPP).

You will need 15 minutes and:
You will be prompted for information to generate a prescription form (for all patients) and an enrollment form (new patients only). Then click Print. This will generate a PDF form, which you must print, sign and fax to 1-866-588-6940.
Start On-Line Prolastin-C Prescription Form
For blank forms, download here: Blank PROLASTIN-C Prescription & Enrollment Form
All online entry of information is secure. No prescription or enrollment information entered online is stored or shared—it is only used to generate the forms for you to fax to Prolastin Direct® Patient Services pharmacy.
In order to get insurance authorization to receive PROLASTIN C, insurance companies request the following information. Please submit documentation of the following information so that we can start the authorization process on your patient’s behalf!
*Note: If you have both genotype and phenotype results, you may provide both, but only one of the two is usually required.
PROLASTIN-C, Alpha1-Proteinase Inhibitor (Human) is indicated for chronic augmentation and maintenance therapy in adults with emphysema due to deficiency of alpha1-proteinase inhibitor (alpha1-antitrypsin deficiency). The effect of augmentation therapy with any alpha1-proteinase inhibitor (alpha1-PI) on pulmonary exacerbations and on the progression of emphysema in alpha1-antitrypsin deficiency has not been demonstrated in randomized, controlled clinical trials. PROLASTIN-C is not indicated as therapy for lung disease in patients in whom severe Alpha1-PI deficiency has not been established.
PROLASTIN-C may contain trace amounts of IgA. Patients with known antibodies to IgA, which can be present in patients with selective or severe IgA deficiency, have a greater risk of developing potentially severe hypersensitivity and anaphylactic reactions. PROLASTIN-C is contraindicated in patients with antibodies against IgA.
The most common drug related adverse reactions during clinical trials in ≥ 1% of subjects were chills, malaise, headache, rash, hot flush, and pruritus.
PROLASTIN-C is made from human plasma. Products made from human plasma may carry a risk of transmitting infectious agents, e.g., viruses, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.
Please see accompanying PROLASTIN-C Full Prescribing Information for complete prescribing details.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.